WitrynaDimerizaton of PDGF fa receptors Balb/c-3T3 cells were incubated in medium containing 0.1 % PPP in the absence or presence of PDGF-AA (50 ng/ml) and cycloheximide (1 ,ug/ml) for 1 h at 37 0C. Witryna1. In the present study, we used a microphysiometer to measure bradykinin-induced acidification responses in IMR-90, a human lung fibroblast cell line, and INT-407, a …
IMR-90 - CCL-186 ATCC
WitrynaPlatelet-derived growth factors (PDGFs) are dimers of A and B polypeptide chains that bind to two receptor tyrosine kinases, PDGF-Rα and PDGF-Rβ.61PDGF is a potent mitogenic factor for connective tissue cells.61PDGF-A is expressed by epithelial cells in the developing lung.62PDGF-A homozygous gene–deleted mice die early in the … WitrynaThe antiparallel arrangement of subunits in PDGFs and the key features of the receptors (i.e., five extracellular Ig-like domains and the split tyrosine kinase domain) are schematically illustrated, together with binding specificities. All subunits are synthesized as precursors, which undergo intracellular dimerization and proteolytic processing. self storage grand prairie tx
PDGF Receptors as Therapeutic Targets - Holland-Frei Cancer …
Witrynacapacity to bind 125I-PDGF-AA displayed a different-sized PDGF receptor mRNA. Claesson-Welsh et al. were then able to identify the second PDGF receptor, PDGFR-a, expressed in U-343 MGa 31L cells (30). Further interest came when the PDGFR-a cDNA was cloned (31,32). Using 125I-binding assays, the pres-ence of both PDGF … WitrynaSchematic illustration of the specificity of binding of platelet-derived growth factor (PDGF) isoforms to PDGFRα and PDGFRβ. Binding of ligands to immunoglobulin-like domains 2 and 3 of the receptors induces dimerization of the receptors, which is further stabilized by direct receptor–receptor interactions, involving immunoglobulin-like domains 4 and 5. WitrynaTwo closely related receptor tyrosine kinases, PDGFRA and PDGFRB, serve as the receptors for the products of the four platelet-derived growth factors genes. These … self storage green mountain falls co